Hepatosplenic Candidiasis Without Prior Documented Candidemia: An Underrecognized Diagnosis?
نویسندگان
چکیده
منابع مشابه
Hepatosplenic Candidiasis Without Prior Documented Candidemia: An Underrecognized Diagnosis?
INTRODUCTION Patients with a history of chemotherapy or stem cell transplantation (SCT) and prolonged neutropenia are at risk for hepatic and/or splenic seeding of Candida. In our experience, hepatosplenic candidiasis (HSC) without documented candidemia often remains unrecognized. CASE PRESENTATIONS We describe three cases of HSC without documented candidemia and the challenges in establishin...
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To determine whether a prior history of hepatosplenic candidiasis resulted in increased Candida-associated morbidity and mortality after marrow transplant, 15 consecutive patients with biopsy-proven hepatosplenic candidiasis were observed prospectively. All patients received amphotericin B before transplant. Amphotericin B was continued at a dose of 0.5 mg/kg/day from conditioning through marro...
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PURPOSE To determine if fluconazole is effective treatment for hepatosplenic candidiasis that has not resolved with amphotericin B and flucytosine treatment. PATIENTS AND METHODS Six patients (ages 3 to 44) with acute leukemia and hepatosplenic candidiasis who did not respond to prior antifungal therapy were treated with fluconazole. RESULTS All six patients had fever and three had nausea a...
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A retrospective study of 23 patients with acute leukaemia and hepatosplenic candidiasis (HSC) was conducted to evaluate clinical treatment characteristics in terms of amount and duration of antifungal agents and to assess treatment outcome. Patients were admitted to two major tertiary care centres between 1990 and 1998. The diagnosis of HSC was based on clinical, blood cultures, histologic and ...
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A 33-year-old man with acute myeloid leukaemia developed neutropenic fever after induction chemotherapy with cytarabine and daunorubicin. The first blood culture was positive for Escherichia coli and the patient was treated with imipenem (500 mg every 6 hours intravenously [IV]). However, the fever persisted and liver function tests were deranged; alkaline phosphatase (ALP) was 166 U/L (referen...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2017
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2017-0019